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PGs exert their effects by specific membrane-localized G protein-coupled receptors on the plasma membrane, and these prostanoid receptors are classified into five basic types: the PGD receptor (DP), the PGE receptor (EP1-4), the PGF receptor (FP), the PGI receptor (IP), and the thromboxane receptor (TP) (Narumiya and Fitzgerald, 2001)

Physical tethering between these organelles facilitates metabolite exchange, whereas shared redox signals synchronize adaptive responses 95,96

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flavone glycoside) The first focused review in 2025 positions prunin as emerging anticancer candidate that modulates cell cycle and apoptosis pathways, with early evidence for combination use and nanoformulations to overcome solubility/bioavailability limits (Rana and Mumtaz, 2025)